At I-70, take Highway 65 South, Sedalia exit. Travel 18 miles south on Highway 65. Take 765 South to the left off Highway 65. At Highway 50 Intersection, travel east to Ohio Street. Turn left for 4 blocks to East 4th Stree. Turn right and hotel on the left. Heading on Highway 50 West to Ohio Street, turn right. Go 4 blocks to East 4th Street. Turn right and hotel on the left. Highway 50 to Ohio Street. Turn left, go 4 blocks to East 4th Street. Turn right. Hotel on the left. Hotel signage reads Hotel Bothwell.

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